(1AR,2Z,4E,14R,15AR)-8-CHLORO-1A,14,15,15A-TETRAHYDRO-9,11-DIHYDROXY-14-METHYL-6H-OXIRENO[E][2]BENZOXACYCLOTETRADECIN-6,12(7H)-DIONE
Radicicol
CAS: 12772-57-5
Molecular Formula: C18H17ClO6
(1AR,2Z,4E,14R,15AR)-8-CHLORO-1A,14,15,15A-TETRAHYDRO-9,11-DIHYDROXY-14-METHYL-6H-OXIRENO[E][2]BENZOXACYCLOTETRADECIN-6,12(7H)-DIONE - Names and Identifiers
(1AR,2Z,4E,14R,15AR)-8-CHLORO-1A,14,15,15A-TETRAHYDRO-9,11-DIHYDROXY-14-METHYL-6H-OXIRENO[E][2]BENZOXACYCLOTETRADECIN-6,12(7H)-DIONE - Physico-chemical Properties
| Molecular Formula | C18H17ClO6 |
| Molar Mass | 364.78 |
| Density | 1.364±0.06 g/cm3(Predicted) |
| Melting Point | 193.5° |
| Boling Point | 656.2±55.0 °C(Predicted) |
| Specific Rotation(α) | D20 +203° (chloroform) |
| Solubility | Soluble in DMSO and ethanol (10mg/mL) |
| Appearance | Yellow powder |
| Color | yellow |
| pKa | 6.29±0.40(Predicted) |
| Storage Condition | −20°C |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
| Sensitive | Sensitive to heat, light and air |
| MDL | MFCD06795865 |
| Use | A potent inhibitor of Hsp90, SRC, and Cox-2 |
(1AR,2Z,4E,14R,15AR)-8-CHLORO-1A,14,15,15A-TETRAHYDRO-9,11-DIHYDROXY-14-METHYL-6H-OXIRENO[E][2]BENZOXACYCLOTETRADECIN-6,12(7H)-DIONE - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. R46 - May cause heritable genetic damage R45 - May cause cancer |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S53 - Avoid exposure - obtain special instructions before use. |
| UN IDs | UN 2811 6.1/PG 3 |
| WGK Germany | 1 |
| RTECS | RR1105000 |
| HS Code | 29322090 |
(1AR,2Z,4E,14R,15AR)-8-CHLORO-1A,14,15,15A-TETRAHYDRO-9,11-DIHYDROXY-14-METHYL-6H-OXIRENO[E][2]BENZOXACYCLOTETRADECIN-6,12(7H)-DIONE - Reference Information
| biological activity | Radicicol is an inhibitor of Hsp90 with an IC50 value of 1 μM. Radicicol target Hsp90, bind to the ATPase domain of Hsp90 and prevent Hsp90 protein maturation, resulting in proteasome degradation. Radicicol is an antifungal antibiotic (antifungal antibiotic) with antimalarial activity that impairs mitochondrial replication by targeting Plasmodium falciparum topoisomerase VIB. |
Last Update：2024-04-09 21:04:16
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View History
(1AR,2Z,4E,14R,15AR)-8-CHLORO-1A,14,15,15A-TETRAHYDRO-9,11-DIHYDROXY-14-METHYL-6H-OXIRENO[E][2]BENZOXACYCLOTETRADECIN-6,12(7H)-DIONE
2-(3,4-bis(allyloxy)phenyl)acetic acid
21937-59-7
Ethanone, 2-amino-1-(2,5-dimethyl-3-furanyl)-
1,3-二溴-2,2-二甲氧基丙烷
321433-65-2
5H-Thiazolo[3,2-a]pyrimidine-6-carbonitrile, 7-(4-chlorophenyl)-2,3-dihydro-5-oxo-
Pseudourea,2-(5-phenylpentyl)-2-thio-,monohydrochloride
[R,(-)]-3-Hydroxy-D-valine
2-[3-[4-[3,4-(Methylenedioxy)phenyl]piperazin-1-yl]propyl]-6,7,8,9-tetrahydro-2H-naphth[2,3-b][1,4]oxazin-3(4H)-one
2-(3,4-bis(allyloxy)phenyl)acetic acid
21937-59-7
Ethanone, 2-amino-1-(2,5-dimethyl-3-furanyl)-
1,3-二溴-2,2-二甲氧基丙烷
321433-65-2
5H-Thiazolo[3,2-a]pyrimidine-6-carbonitrile, 7-(4-chlorophenyl)-2,3-dihydro-5-oxo-
Pseudourea,2-(5-phenylpentyl)-2-thio-,monohydrochloride
[R,(-)]-3-Hydroxy-D-valine
2-[3-[4-[3,4-(Methylenedioxy)phenyl]piperazin-1-yl]propyl]-6,7,8,9-tetrahydro-2H-naphth[2,3-b][1,4]oxazin-3(4H)-one